ABC has remade faces and totally renovated homes. So how about remaking lives? Possibilities: 
Extreme Makeover: Mind Edition, where people get help from life coaches, psychologists, clergy, family and friends. Get Dr. Phil to host this puppy, perhaps. Or Oprah. 
Extreme Makeover: Love Life Edition. This time, instead of focusing on outer beauty, it would be about finding the right person by setting up dates, trying speed dating, sex therapy, dance lessons, speech therapy, working out, whatever.
Extreme Makeover: Career Edition. People would submit their sob stories about desperating needing a better or different job, and the show would find them one, even if it takes all sorts of coaching and interviews.